Monday, October 17, 2016

Cloud Computing for Next Generation Sequencing

DNA Sequencing refers different methods and technologies, which are used for determining the sequence or order of the nucleotide bases-adenine, guanine, cytosine, and thymine in a DNA molecule. The adverse use of advanced DNA sequencing i.e next generation sequencing has extremely accelerated biological research and discovery day by day.

DNA Sequencing was conducted through extensively laborious and rigorous methods before 1970, but the journey of advance DNA sequencing started with Maxam Gilbert Sequencing. The Chain-termination methods, Dye-terminator sequencing, High-throughput sequencing, Lynx Therapeutics' Massively Parallel Signature Sequencing (MPSS), Polony Sequencing have come into the limelight for developing the technology. 454 pyrosequencing, Illumina (Solexa) sequencing, SOLiD sequencing, DNA nanoball sequencing etc. have started the next generation sequencing using different types of innovative technology.

The advent of next generation Sequencers are contributing a huge amount of data for analysis. However, it has increased the complexities of genomic sequencing workflows but enriched biological discoveries to the greater extent. A tightly integrated, scalable, high-performance computing platform with intelligent data management systems and uncompromised security could make all the difference in advancing DNA Sequencing. Moreover, transparency of the huge data generated by the sequencers must be decoded by the trustworthy platform.

Today’s Bioinformatics moving towards technology advancement and leveraging cloud computing to answer the parallel processing of gamut of data securely. Cloud computing infrastructures expected to be more scalable and transparent to make usability more conducive to Bioinformatics data scientists.